First sentence: Why this is the first line? This paragraph is the first sentence because it introduces the main topic of the text, which is about cancer caused by HPV. It gives a broad overview of the number of people diagnosed with this cancer each year. This follows the rule of Topic Sentence. Why other lines are not chosen? Paragraph 2 starts with "It is" which makes it dependent on prior context. Paragraph 3 starts with "In women" which also needs context. Paragraph 4 starts with "While in men" which is not independent. Paragraph 5 starts with "HPV also" which refers back to the topic and is not independent.

Concluding sentence: Why this is the last line? This paragraph is the last sentence because it summarizes the different cancers caused by HPV. It wraps up the discussion about HPV and its effects, following the Summary Style rule.

Paragraph pairs:

• Pair 1 (Paragraph 1 → Paragraph 2): Paragraph 2 connects to Paragraph 1 because it explains more about HPV. It uses the Connector strategy by starting with "It is" which refers back to HPV mentioned in Paragraph 1.
• Pair 2 (Paragraph 2 → Paragraph 3): Paragraph 3 connects to Paragraph 2 because it gives specific information about the effects of HPV in women. This follows the Broader to Specific Strategy, where the general statement about HPV leads to a specific case.
• Pair 3 (Paragraph 3 → Paragraph 4): Paragraph 4 connects to Paragraph 3 because it discusses another effect of HPV, but in men. This shows a Logical Order as it continues the discussion about HPV's effects.
• Pair 4 (Paragraph 4 → Paragraph 5): Paragraph 5 connects to Paragraph 4 because it continues to explain other cancers caused by HPV. This follows the Same Theme strategy, as both paragraphs discuss the types of cancer related to HPV.